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Physiological seawater refers to sterilized and diluted natural seawater that has been adjusted to match the ionic concentration of human blood plasma (isotonic). It contains a broad spectrum of minerals and trace elements found in ocean water. The solution is typically used for nasal irrigation, oral supplementation, or topical applications. Its mechanism is primarily based on restoring mineral balance and supporting cellular function due to its similarity with the body's extracellular fluid. Unlike standard saline (0.9% sodium chloride), physiological seawater includes additional electrolytes such as magnesium, calcium, potassium, and trace elements[1]. It is not considered toxic when properly prepared and sterilized; it can be used for hydration support or as an adjunct in certain therapies under medical supervision[1]. Primary indications include nasal hygiene/irrigation and mineral supplementation.
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