physiological serum (Centre Hospitalier Universitaire de Nice)

Physiological serum, commonly known as normal saline or 0.9% sodium chloride solution, is a standard isotonic crystalloid used for fluid resuscitation, maintenance, and as a vehicle for intravenous drug administration. In the context of neurocritical care, it is frequently used to maintain intravascular volume and cerebral perfusion pressure. In a Phase 3 clinical trial conducted by the Centre Hospitalier Universitaire de Nice, physiological serum is being evaluated as the control comparator against molar sodium lactate in patients with severe aneurysmal subarachnoid hemorrhage. The study aims to determine the comparative effects of these fluids on cerebral hemodynamics, specifically mean transit time (MTT) measured by perfusion CT, to mitigate complications such as vasospasm and delayed neurological deficits.

Other names

normal saline0.9% sodium chlorideisotonic salineisotonic sodium chloride solutionsaline solutionsérum physiologique