Drug intelligence / Profile preview

Phytoestrogens + Isosorbide mononitrate + N-acetyl cysteine

Development stage
Unknown
Lead developer
AstraZeneca
Modality
Drug Delivery Systems
Administration
Oral
01

Overview

This is a combination of three distinct substances: Phytoestrogens, Isosorbide mononitrate, and N-acetyl cysteine (NAC). Isosorbide mononitrate is a nitrate vasodilator used to prevent angina attacks by relaxing blood vessels, reducing the heart's workload. It acts as a prodrug for nitric oxide, activating soluble guanylyl cyclase and increasing cGMP to relax smooth muscle cells. Common side effects include headache, dizziness, and low blood pressure. N-acetyl cysteine is an antioxidant derived from L-cysteine. As a prescription drug, it treats acetaminophen overdose. It also has mucolytic effects and is used for bronchial diseases and COPD. It may help prevent contrast-induced nephropathy and potentially improve chest pain when used with nitroglycerin. NAC is also available as a dietary supplement. Phytoestrogens are plant-derived compounds with estrogen-like effects, found in foods like soy and flaxseeds. The specific combination of these three components is not described in the provided search results. It appears to be a unique formulation whose exact intended use and efficacy are unclear. Based on the individual components, potential applications might relate to cardiovascular health (isosorbide mononitrate, NAC) possibly combined with hormonal balance considerations (phytoestrogens).

02

Targets

sGC (Soluble Guanylyl Cyclase)ESR1 (ERα)

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