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phytomenadione
- Development stage
- Approved
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral, Intravenous, Intramuscular, Subcutaneous
01
Overview
Phytomenadione is a synthetic form of vitamin K1 (also known as phylloquinone or phytonadione), an essential fat-soluble vitamin. It is used to treat and prevent bleeding disorders caused by vitamin K deficiency or interference with vitamin K activity. The drug acts as a cofactor for the hepatic synthesis of blood clotting factors II (prothrombin), VII, IX, and X as well as anticoagulant proteins C and S. Phytomenadione is indicated for conditions such as warfarin overdose (anticoagulant-induced prothrombin deficiency), hypoprothrombinemia secondary to antibacterial therapy or malabsorption syndromes (e.g., obstructive jaundice), and prevention/treatment of hemorrhagic disease in newborns. It can be administered orally or via injection[1][2][4][5][6][7].
- Brand names
- MephytonAquamephytonKonakionVitamin K1
- Other names
- phylloquinonephytonadione
02
Targets
GGCX (Vitamin K-dependent gamma-glutamyl carboxylase)
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