Drug intelligence / Profile preview

phytosterol + hawthorn

Development stage
Preclinical
Lead developer
Unilever
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

**Phytosterol + hawthorn** is a combination product consisting of phytosterols (plant-derived sterols) and hawthorn (typically, extracts from Crataegus species) formulated for oral intake, most commonly as a dietary supplement for the support of cardiovascular health and the management of blood lipid levels. Phytosterols inhibit the intestinal absorption of dietary cholesterol, leading to lower blood LDL cholesterol. Hawthorn is rich in flavonoids and triterpenic acids and is reported to exert multiple cardiovascular benefits, including mild blood pressure and cholesterol-lowering actions, antioxidant, anti-inflammatory, and possible mild positive inotropic (heart-strengthening) effects. Preclinical and limited clinical studies suggest these two ingredients may have additive lipid-lowering effects, but robust clinical efficacy and safety data on the combination are lacking. The combination is most often positioned for individuals seeking non-prescription support for hyperlipidemia or mild cardiovascular symptoms, and is not a pharmaceutical-grade drug approved for specific cardiovascular indications[3][5].

Other names
phytosterols + hawthornplant sterols + hawthorn
02

Targets

SOAT1 (Sterol O-acyltransferase)NPC1L1 (Niemann-pick C1-Like 1 transporter)

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