Pi Xu Er Hao Fang

Pi Xu Er Hao Fang (脾虚二号方) is a traditional Chinese medicine (TCM) formula used primarily for the treatment of spleen deficiency syndromes, particularly those manifesting as chronic diarrhea or digestive dysfunction. The formula is based on TCM theory, which attributes symptoms such as loose stools, fatigue, and poor appetite to "spleen qi deficiency." While the exact herbal composition of Pi Xu Er Hao Fang can vary by practitioner or region and is not standardized in major English-language pharmacopoeias, it typically contains a combination of herbs aimed at strengthening the spleen, improving digestion, and restoring gut microbiota balance. Mechanistically, these formulas are believed to work by modulating intestinal flora—promoting beneficial bacteria like Lactobacillus and Bifidobacterium—thereby improving gastrointestinal function[1]. There is evidence that polysaccharides from certain component herbs (e.g., Atractylodes macrocephala) serve as prebiotics to support probiotic growth[1]. This type of formula is commonly used in China for conditions such as irritable bowel syndrome with diarrhea predominance (IBS-D), chronic enteritis due to spleen deficiency, and other related digestive disorders.

Other names

脾虚二号方