piceatannol tetraglycolate

Piceatannol tetraglycolate is a synthetic stilbenoid derivative developed primarily as a stable and skin-permeable prodrug of piceatannol. By substituting the four hydroxyl groups of the naturally occurring polyphenol piceatannol with glycolic acid moieties, the molecule exhibits significantly improved chemical stability and enhanced transdermal delivery compared to its parent compound. Upon application to the skin, it is believed to undergo enzymatic cleavage by esterases to release piceatannol and glycolic acid. Its primary mechanism of action involves the potent inhibition of tyrosinase, the rate-limiting enzyme in melanin biosynthesis, thereby suppressing melanogenesis. Developed by companies like Biospectrum, it is investigated for use in dermatological applications to treat hyperpigmentation disorders, such as melasma and solar lentigines, and as an active ingredient in high-performance cosmeceuticals for skin brightening and antioxidant protection.

Other names

glycolic acid tetrasubstituted piceatannolPiceatannol-3,4,3',5'-O-tetraglycolate3,3',4,5'-tetra-O-glycoloyl-piceatannol