piceid + resveratrol

Piceid + resveratrol is a combination of two related stilbenoid polyphenols. Piceid, also known as polydatin, is the 3-beta-D-glucoside of resveratrol and serves as its primary natural precursor. While piceid is often converted to resveratrol in the gastrointestinal tract via glycosidases, it also exhibits distinct pharmacokinetic properties, including potentially higher oral bioavailability due to active transport mechanisms. Together, these compounds act as potent antioxidants and anti-inflammatory agents. Their primary mechanism of action involves the activation of Sirtuin 1 (SIRT1), a NAD+-dependent deacetylase associated with longevity and metabolic regulation, and the inhibition of pro-inflammatory pathways such as NF-kappaB and cyclooxygenase (COX) enzymes. This combination is frequently utilized in dietary supplements derived from *Polygonum cuspidatum* (Japanese Knotweed) for indications including cardiovascular health, metabolic syndrome, and neuroprotection.

Brand names

Resverasol

Other names

polydatin + resveratrol3,5,4'-trihydroxystilbene-3-O-beta-D-glucoside + 3,5,4'-trihydroxystilbene