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pilose antler extracts
- Development stage
- Preclinical
- Modality
- Recombinant Proteins and Enzymes, Peptides
- Administration
- Oral, Topical, Intraperitoneal (mainly In Animal Studies)
01
Overview
Pilose antler extracts are bioactive preparations derived from the unossified, fast-growing antlers of deer (commonly sika deer, *Cervus nippon* Temminck), widely used in traditional Chinese medicine (TCM). They contain a complex mixture of peptides, proteins, and other biomolecules, most notably pilose antler peptide (PAP). These extracts exhibit **anti-inflammatory, antioxidant, immunomodulatory, neuroprotective, and anti-aging activities**. Reported mechanisms include modulation of several signaling pathways (such as AMPK/Sirt1/NF-κB/NLRP3, TGF-β/SMAD, AKT, and Wnt) that mediate inflammation, oxidative stress, and tissue regeneration. Primary research suggests applications in **depression, psoriasis, heart disease, and androgenetic alopecia**, but strong clinical evidence for many indications is lacking.
- Other names
- pilose antlerCornu Cervi Pantotrichum extractsPAEs
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)NF-κBSIRT1 (NAD-dependent protein deacetylase sirtuin-1)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)AKT (RAC-alpha serine/threonine-protein kinase)SMAD2 (Mothers against decapentaplegic homolog 2)TGFB1 (Transforming growth factor Beta-1 proprotein)
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