pimonidazole

Pimonidazole is a small molecule belonging to the nitroimidazole class, primarily used as a hypoxia marker in research and clinical diagnostics. It is selectively reduced in hypoxic environments—such as those found within solid tumors—where it forms stable adducts with thiol groups in proteins, peptides, and amino acids. This property allows for the identification and quantification of hypoxic cells using immunohistochemical techniques. Pimonidazole has also been investigated for its radiosensitizing properties due to its ability to deplete radioprotective thiol compounds in tumor cells, potentially making them more susceptible to radiation therapy. Its main applications are as a diagnostic tool for assessing tumor hypoxia in cancers such as prostate cancer and head and neck cancer[1][2][5][8].

Brand names

Hypoxyprobe-1Hypoxyprobe1Hypoxyprobe 1

Other names

pimonidazole hydrochloridepimonidazole HCl