pimpinella brachycarpa extract

Pimpinella brachycarpa extract (PBE) is a plant-derived herbal medicine currently in the research phase for the treatment of periodontitis. Derived from a plant traditionally used in Asian medicine for its anti-inflammatory and antimicrobial properties, PBE has demonstrated significant efficacy in preclinical models of ligature-induced periodontitis. Its therapeutic effect is mediated through the suppression of pro-inflammatory cytokines, specifically tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β), and the inhibition of osteoclastogenesis, which prevents alveolar bone loss. Chemical analysis identifies chlorogenic acid as a primary active constituent responsible for these bone-protective and anti-inflammatory effects. Studies published in 2025 indicate that oral administration of the extract can significantly reduce inflammatory responses and bone resorption, showing potential as a therapeutic agent for periodontal diseases.

Other names

Cham-namul extract