Drug intelligence / Profile preview

Pinorox

Development stage
Preclinical
Lead developer
Ambe Phytoextracts
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Pinorox is a proprietary, standardized botanical extract derived from the bark of *Pinus roxburghii* (Chir Pine), characterized by a high concentration of bioactive polyphenols, including taxifolin and proanthocyanidins. Developed by Pino Biologicals, it is primarily intended for topical dermatological applications to mitigate visible signs of facial aging such as wrinkles, fine lines, and hyperpigmentation (dark spots). The extract functions through a multi-modal mechanism: it acts as a potent antioxidant by scavenging reactive oxygen species (ROS) to prevent oxidative stress-induced cellular damage, inhibits matrix metalloproteinases (MMPs) to preserve the structural integrity of the dermal collagen matrix, and inhibits tyrosinase activity to regulate melanin production. Pinorox is currently being evaluated in clinical trials to assess its safety, efficacy, and tolerability as a cosmeceutical or therapeutic agent for skin rejuvenation.

Brand names
Pinorox
Other names
Pinus roxburghii bark extractChir Pine extract
02

Targets

TYR (Tyrosinase)MMP12 (Macrophage Metalloelastase)

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