Drug intelligence / Profile preview

pinus contorta pollen

Development stage
Unknown
Lead developer
Ares Life Sciences
Administration
Subcutaneous, Intradermal, Topical
01

Overview

Pinus contorta pollen, derived from the Lodgepole Pine, is utilized primarily as an allergenic extract for the diagnosis and treatment of Type I hypersensitivity reactions. In clinical practice, it is employed as a diagnostic tool in skin prick or intradermal testing to identify patients with specific sensitization to pine allergens. Therapeutically, it is used in allergen-specific immunotherapy (ASIT), where the administration of gradually increasing doses of the extract aims to induce immunological tolerance. The mechanism of action involves a complex modulation of the immune system, including the induction of regulatory T cells (Tregs), a shift from a Th2-dominated to a Th1-dominated cytokine profile, and the production of 'blocking' IgG4 antibodies that compete with IgE for allergen binding. Beyond its pharmaceutical use, Pinus contorta pollen is also marketed as a dietary supplement, often cited for its nutrient density and purported effects on hormonal balance, although these claims are less rigorously supported by clinical evidence than its use in allergy.

Brand names
Lodgepole Pine Pollen Allergenic Extract
Other names
Lodgepole pine pollenPinus contorta extract
02

Targets

IgE (Immunoglobulin E)

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