Drug intelligence / Profile preview

pinus massoniana extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Pinus massoniana extract (PMBE) is a natural product derived from the bark of the Chinese red pine (*Pinus massoniana*), a species traditionally used in Chinese medicine. The extract is characterized by a high concentration of bioactive proanthocyanidins, particularly the B series procyanidins, which constitute approximately 26-28% of its composition. PMBE has been extensively studied in preclinical research for its potent anticancer properties across various malignancies, including hepatocellular carcinoma, ovarian cancer, cervical cancer, and breast cancer. Its therapeutic effects are mediated through the induction of apoptosis, cell cycle arrest, and the inhibition of tumor cell migration. Beyond oncology, the extract has demonstrated antioxidant, hepatoprotective, and antihypertensive activities. While it shows promise as a candidate for pharmaceutical development and as a functional food additive, it currently remains in the research and discovery phase.

Other names
Pinus massoniana bark extractChinese red pine bark extract
02

Targets

AKR1B10 (Aldo-keto reductase family 1 member B10)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)THBS1 (Thrombospondin-1)

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