PIP4K2A-mimetic peptides

PIP4K2A-mimetic peptides are a novel class of peptide-based therapeutics designed to mimic the tumor-suppressive function of phosphatidylinositol-5-phosphate 4-kinase type 2 alpha (PIP4K2A). PIP4K2A has been identified as a negative regulator of tumor progression, particularly in cancers deficient in Phosphatase and Tensin Homolog (PTEN). These peptides, derived from the N- and C-terminal regions of the human PIP4K2A protein, aim to restore or simulate PIP4K2A activity to inhibit uncontrolled cell proliferation. Preclinical studies have demonstrated that these peptides, specifically peptide-1 and peptide-2, exhibit selective cytotoxicity against PTEN-deficient cancer cells, such as glioma, while sparing normal cells. Peptide-1 has shown significant antitumor efficacy in patient-derived xenograft (PDX) models, suggesting potential for clinical translation in treating PTEN-deficient malignancies.

Other names

PIP4K2A-mimetic peptide-1PIP-4K2A-mimetic peptide-1PIP 4K2A-mimetic peptide-1PIP4K2A-mimetic peptide-2PIP-4K2A-mimetic peptide-2PIP 4K2A-mimetic peptide-2