pipamperone

Pipamperone is a typical antipsychotic of the butyrophenone family, developed by Janssen Pharmaceutica in the early 1960s for the treatment of schizophrenia. It is primarily used as an antipsychotic and sedative, with additional benefits in managing agitation and sleep disturbances. Its mechanism of action involves antagonism at several neurotransmitter receptors, most notably serotonin (5-hydroxytryptamine) receptors—especially 5‑HT2A—and dopamine receptors (D2, D3, D4), with higher selectivity for 5‑HT2A and D4 over D2. It also blocks α1‑adrenergic and α2‑adrenergic receptors. The drug has relatively weak neuroleptic activity compared to other typical antipsychotics due to its moderate dopamine antagonism but pronounced serotonergic antagonism. This pharmacological profile led some to consider pipamperone a forerunner or even an early example of atypical antipsychotics[1][3][4].

Brand names

DipiperonDipiperalPiperonilPiperonylPropitan

Other names

CarpiperoneFloropipamideFluoropipamidePipamperonaPipamperonumDipiperonePipaneperone