piper crocatum extract

Piper crocatum extract is a botanical substance derived from the red betel leaf, a plant native to Indonesia traditionally utilized in herbal medicine. The extract is characterized by a high concentration of bioactive compounds, including flavonoids, polyphenols, alkaloids, tannins, and steroids, which impart antioxidant, anti-inflammatory, and hypoglycemic properties. It is currently being investigated as a functional food ingredient, often delivered in the form of cookies or gels, for the management and prevention of chronic diabetic complications such as diabetic neuropathy, nephropathy, and dyslipidemia. Its therapeutic mechanism involves the modulation of inflammatory biomarkers like Matrix metalloproteinase-9 (MMP-9) and Neutrophil gelatinase-associated lipocalin (NGAL), as well as the regulation of cytokine expression and oxidative stress pathways. Clinical development is primarily academic-led, focusing on its potential as an adjunct therapy to stabilize blood glucose and protect against organ-specific damage in metabolic diseases.

Other names

red betel leaf extractsirih merah extractPiper crocatum Ruiz & Pav. extract