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pirarubicin + vinorelbine
- Development stage
- Preclinical
- Lead developer
- Pierre Fabre
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A combination chemotherapy regimen consisting of pirarubicin (an anthracycline antibiotic) and vinorelbine (a semi-synthetic vinca alkaloid). This combination is used primarily in the treatment of locally advanced breast cancer (LABC), particularly in elderly patients. The regimen works through dual mechanisms: pirarubicin intercalates with DNA and inhibits topoisomerase II, while vinorelbine interferes with tubulin polymerization, disrupting mitotic spindle formation and preventing cell division.
02
Targets
TOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))
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