piritramide

Piritramide is a synthetic opioid analgesic primarily used for the management of moderate to severe pain, especially in postoperative and posttraumatic settings. It was discovered at Janssen Pharmaceutica in 1960 and has been marketed for over 30 years in several European countries, including Austria, Belgium, Germany, Slovenia, and the Netherlands[3][4]. Piritramide acts as an agonist at mu-opioid receptor in the central nervous system (CNS), mimicking endogenous opioids to produce analgesia[4]. Compared to morphine, it is slightly less potent (about 0.65–0.75 times) but may have a more rapid onset of action due to its high lipophilicity[3][6]. The drug is administered parenterally—most commonly intravenously or intramuscularly—and is not available in the United States[2][3][4]. Its side effect profile is similar to that of morphine but may include less frequent nausea and vomiting; sedation remains dose-related and common[6].

Brand names

DipidolorPiridolanPirium

Other names

PiritramidaPiritramidumDipiritramidePirinitramide