Drug intelligence / Profile preview

pitavastatin calcium

Development stage
Unknown
Lead developer
Korea Arlico Pharm
Modality
Small Molecules
Administration
Oral
01

Overview

ALC-2207 is a generic formulation of **pitavastatin calcium**, a third-generation HMG-CoA reductase inhibitor (statin) developed by **Korea Arlico Pharm**. It is indicated for the treatment of primary hypercholesterolemia and mixed dyslipidemia. Pitavastatin works by competitively inhibiting the enzyme HMG-CoA reductase, which catalyzes the rate-limiting step in cholesterol biosynthesis in the liver. This inhibition leads to an increase in the expression of LDL receptors on hepatocyte membranes, enhancing the uptake and catabolism of LDL cholesterol from the circulation. ALC-2207 was developed as a generic alternative to the reference drug **Livalo** (marketed by JW Pharmaceutical in Korea). It is administered orally and is characterized by its potent LDL-lowering effects and minimal metabolism by the cytochrome P450 system, which reduces the potential for drug-drug interactions compared to other statins.

Brand names
Pitavaco
Other names
pitavastatinpitavastatin calcium
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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