pivampicillin

Pivampicillin is a semisynthetic, orally active pivaloyloxymethyl ester of ampicillin and serves as a prodrug to enhance the oral bioavailability of ampicillin due to its increased lipophilicity. After oral administration, it is rapidly hydrolyzed by non-specific esterases in the body to release active ampicillin along with formaldehyde and pivalic acid. Ampicillin exerts its antibacterial effect by binding to and inactivating penicillin-binding proteins (PBPs) on the bacterial cell wall's inner membrane. This action inhibits peptidoglycan cross-linking necessary for cell wall strength and rigidity, leading to bacterial cell lysis. Pivampicillin is primarily indicated for treating susceptible bacterial infections such as gonococcal urethritis and other infections responsive to ampicillin[1][2][3][5][6].

Brand names

PondocillinMiraxid

Other names

pivaloylampicillinpivampicilinapivampicilline33817-20-8