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pkc-alpha siRNA
- Development stage
- Unknown
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Intratumoral
01
Overview
pkc-alpha siRNA refers to small interfering RNA molecules designed to selectively silence the expression of protein kinase C alpha (PKC-α / PRKCA) via RNA interference. PKC-α is a serine/threonine kinase involved in key cellular processes including proliferation, differentiation, and migration, and is frequently overexpressed in various malignancies such as breast cancer, melanoma, and neuroblastoma. While primarily utilized as a research-use-only laboratory reagent to study intracellular signaling pathways, preclinical studies have also explored its therapeutic potential, often utilizing nanoparticle delivery systems (such as carbonate apatite nanoparticles) to suppress tumor growth and metastasis in animal models.
- Other names
- PKC-alpha siRNAPRKCA siRNAprotein kinase C alpha siRNA
02
Targets
PRKCA (Protein kinase C alpha)
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