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PKNPs

Development stage: Preclinical
Lead developer: Chinese Academy of Sciences
Modality: Small Molecules, Peptide-Drug Conjugates → Peptide Conjugates → Peptides, Nanoparticles → Drug Delivery Systems

Overview

**PKNPs** are an experimental, target-responsive supramolecular nanoparticle system developed for **Alzheimer's disease**. The particles are formed by self-assembly of a porphyrin-KLVFF peptide conjugate, in which the KLVFF sequence recognizes amyloid-beta and the porphyrin moiety acts as a light-responsive photosensitizer. Under irradiation, PKNPs produce a photothermal effect that improves blood-brain barrier penetration; interaction with amyloid-beta induces morphological disassembly and switches the construct toward photodynamic activity, enabling selective photooxygenation of amyloid-beta and inhibition of its aggregation. The system showed anti-amyloid and neuroprotective activity in preclinical Caenorhabditis elegans models, but it is not a marketed medicine or a registered clinical-stage product.

Other names: Aβ target-driven supramolecular self-assemblyPKNPs

Targets

Aβ (Amyloid-beta peptides and aggregates)

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