Drug intelligence / Profile preview

placebo + DA-9701

Development stage
Unknown
Lead developer
Dong-A Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination of placebo and DA-9701. DA-9701 (Motilitone) is a multi-targeting botanical drug developed for the treatment of functional dyspepsia and gastrointestinal dysfunction. It consists of extracts from Corydalis Tuber and Pharbitidis Semen, both used in traditional medicine for their analgesic and prokinetic effects. The drug acts via multiple mechanisms, including prokinetic effects (enhancing gastric emptying), fundus relaxation, visceral analgesia, antagonism at dopamine D₂ receptors, antagonism at serotonin 5-HT₃ receptors, and agonism at serotonin 5-HT₄ receptors involved in gastrointestinal motility. Placebo is an inert substance with no pharmacological activity used as a control in clinical trials[1][3][10].

Brand names
Motilitone
02

Targets

HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))UGT1A1 (UDP-glucuronosyltransferase 1A1)HTR3A (5-hydroxytryptamine receptor 3A)HTR4 (5-Hydroxytryptamine receptor 4)DRD2 (Dopamine D2 Receptor)MLNR (Human motilin receptor)

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