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placebo + fluorouracil + cisplatin
- Development stage
- Unknown
- Lead developer
- CStone Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Placebo + fluorouracil + cisplatin is a combination therapy used as the control arm in the GEMSTONE-304 Phase 3 clinical trial conducted by CStone Pharmaceuticals. This regimen consists of a placebo administered in conjunction with a standard chemotherapy doublet of fluorouracil and cisplatin (FP). Fluorouracil is an antimetabolite that inhibits thymidylate synthase, while cisplatin is a platinum-based agent that causes DNA cross-linking. The combination was evaluated as a first-line treatment for patients with unresectable locally advanced, recurrent, or metastatic esophageal squamous cell carcinoma (ESCC) to serve as a comparator for the PD-L1 inhibitor sugemalimab.
- Other names
- Placebo + FPPlacebo + Fluorouracil + Cisplatin
02
Targets
TS (Thymidylate synthase)DNA
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