placebo + morphine

placebo + morphine is a combination treatment regimen consisting of a placebo and the opioid analgesic morphine, specifically used as the comparator arm in the Phase II GAPP-2 clinical trial (NCT03275012). This study, sponsored by Pharmaceutical Research Management srl, evaluates the safety and efficacy of gabapentin as an adjunctive therapy to morphine in pediatric patients (aged 3 months to 18 years) suffering from severe chronic neuropathic or mixed pain. Morphine serves as the background analgesic, acting as a potent agonist of the mu-opioid receptor to modulate pain signaling in the central nervous system. The placebo component is a liquid oral formulation designed to match the gabapentin suspension used in the active arm, facilitating a double-blind study design to determine if the addition of gabapentin provides superior pain control compared to morphine monotherapy.

Other names

Placebo plus morphine