Drug intelligence / Profile preview

placebo + olanzapine

Development stage
Unknown
Lead developer
Eli Lilly
Modality
Small Molecules
Administration
Oral, Intramuscular
01

Overview

This is a combination of a placebo (an inert substance with no active pharmacological effect) and olanzapine, an atypical antipsychotic medication. Olanzapine acts primarily as an antagonist at dopamine D2 and serotonin 5HT2A receptors, rebalancing these neurotransmitters to improve symptoms in conditions such as schizophrenia and bipolar disorder. The combination "placebo + olanzapine" is not a marketed pharmaceutical product but may be used in clinical trials where one group receives both agents for blinding or control purposes. Olanzapine is developed for the treatment of schizophrenia, bipolar I disorder (including manic/mixed episodes), and agitation associated with these disorders[1][2][3][6]. Placebo has no therapeutic effect.

02

Targets

DRD4 (Dopamine D4 Receptor)HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)HRH1 (Histamine H1 Receptor)HTR3A (5-hydroxytryptamine receptor 3A)mAChR (Muscarinic acetylcholine receptors)HTR6 (5-hydroxytryptamine receptor 6)DRD1 (Dopamine D1 Receptor)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)ADRA1A (α1A)

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