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Placebo to upadacitinib is an inactive control substance developed by AbbVie for use in clinical trials evaluating upadacitinib (Rinvoq), a selective Janus kinase 1 (JAK1) inhibitor. In the context of atopic dermatitis, it is formulated as an oral extended-release tablet to match the appearance and administration schedule of the active drug. It serves as a comparator in Phase 3 studies, such as the 'Heads Up' trial, to establish a baseline for safety and efficacy. As a placebo, it contains no active pharmaceutical ingredients and does not exert a therapeutic effect.
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