placebo vaginal ring

The placebo vaginal ring is an inactive control device developed by the International Partnership for Microbicides (IPM) for use in clinical trials evaluating the safety and efficacy of the dapivirine vaginal ring for HIV-1 prevention. It is a flexible, platinum-catalyzed-cured silicone matrix ring that is physically and chemically identical to the active dapivirine ring (Ring-004) but contains no active pharmaceutical ingredient. This placebo was utilized as a comparator in randomized, double-blind trials, including the Phase 3 ASPIRE (MTN-020) and The Ring Study (IPM-027), to provide a baseline for assessing the reduction in HIV-1 infection risk and the safety profile of the long-acting microbicide delivery system in women.

Other names

Placebo Vaginal RingPlacebo VR