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Drug intelligence / Profile preview
placenta-derived gp96 injection
- Development stage
- Unknown
- Lead developer
- Boao Evergrande International Hospital
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Parenteral
01
Overview
Placenta-derived gp96 injection is an experimental biologic therapy being investigated for the treatment of amyotrophic lateral sclerosis (ALS). gp96, also known as heat shock protein 90 kDa beta member 1 (HSP90B1) or glucose-regulated protein 94 (GRP94), is a molecular chaperone located in the endoplasmic reticulum that plays a critical role in protein folding and the cellular stress response. In the context of ALS, this placenta-derived formulation is hypothesized to exert neuroprotective effects and modulate the immune system to slow disease progression. It is currently being evaluated in a Phase 0 clinical trial in China to assess safety and preliminary efficacy, with a focus on clinical symptom changes and immunological laboratory markers.
- Other names
- gp96 injectiongp-96 injectiongp 96 injectionplacenta-derived gp96
02
Targets
LRP1 (Prolow-density lipoprotein receptor-related protein 1)HSP90B1 (GRP94)
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