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placenta-extracted heat shock protein preparation
- Development stage
- Unknown
- Lead developer
- Boao Evergrande International Hospital
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Subcutaneous, Intramuscular
01
Overview
Placenta-extracted heat shock protein preparation is a biologic therapeutic derived from human placental tissue, enriched for various heat shock proteins (HSPs) such as HSP70, HSP90, and gp96. Developed by Boao Evergrande International Hospital, this preparation is being investigated in pilot clinical studies for its immunomodulatory potential in treating autoimmune diseases, including ankylosing spondylitis, systemic lupus erythematosus, and rheumatoid arthritis. The mechanism involves the interaction of HSPs with antigen-presenting cells (APCs) via receptors like CD91 and Toll-like receptors (TLRs), which can lead to the modulation of T-cell responses and the induction of regulatory T cells (Tregs), potentially restoring immune tolerance and reducing systemic inflammation.
- Other names
- placenta-extracted heat shock proteinHSP preparationplacental heat shock proteins
02
Targets
LRP1 (Prolow-density lipoprotein receptor-related protein 1)TLR4 (Toll-like receptor 4)TLR2 (Toll-like Receptor 2)HSP90B1 (GRP94)
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