placental mesenchymal stem cell-derived exosomes

Placental mesenchymal stem cell-derived exosomes are extracellular vesicles secreted by mesenchymal stem cells (MSCs) isolated from human placental tissue. These nano-sized vesicles function as cell-free therapeutic agents that encapsulate and transport a variety of bioactive molecules, including proteins, lipids, and specific microRNAs (such as hsa-let-7i-5p, miR-143, and miR-139-5p). They mediate intercellular communication and exert potent anti-inflammatory, antioxidant, anti-apoptotic, and pro-regenerative effects. By modulating critical signaling pathways—such as the NF-κB, MAPK, and PTEN/AKT pathways—these exosomes are being investigated for their ability to repair tissue damage in conditions like acute lung injury, intrauterine adhesions, chemotherapy-induced ovarian dysfunction, and spinal cord injury. They are also utilized in regenerative aesthetics for skin biostimulation and can serve as specialized drug delivery vehicles for natural compounds like berberine.

Other names

Human placental mesenchymal stem cell-derived exosomesPlacenta-derived mesenchymal stem cell exosomeshPMSC-derived exosomesPMSC exosomes