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plague vaccine F1 + rV
- Development stage
- Phase 2
- Lead developer
- Jiangsu Provincial Center for Disease Control and Prevention
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
A recombinant subunit vaccine designed to protect against plague caused by *Yersinia pestis*. It consists of two primary antigens: the natural Fraction 1 (F1) capsular protein and a recombinant version of the V (LcrV) antigen. These antigens are critical for the virulence of *Y. pestis* and are known to provide synergistic protection against both bubonic and pneumonic plague. The vaccine is being developed by the Jiangsu Provincial Center for Disease Control and Prevention and has been evaluated in Phase 2 clinical trials using various immunization regimens (e.g., 0-1-6 and 0-2-6 months). The formulation typically includes an adjuvant to enhance immunogenicity.
- Other names
- plague subunit vaccine (F1+rV)subunit vaccine of plague vaccine (F1+ rV)
02
Targets
LcrV (V antigen)F1 antigen (F1 capsular antigen)
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