planar catechin

Planar catechin is a synthetic catechin analogue in which the catechol and chroman moieties of natural (+)-catechin are constrained to be coplanar, resulting in a "planar" structure. This modification results in **significantly higher antioxidant activity**—approximately 5 to 10 times greater radical-scavenging ability than native catechin—owing to increased electron delocalization. Planar catechin demonstrates enhanced protection against oxidative DNA damage, efficient free radical scavenging (notably DPPH), and less pro-oxidant activity compared to catechin[1][2][3][5][7]. Notably, it also exhibits **anti-cancer properties**, selectively inducing cytotoxicity in cancer cells—mainly through a decrease in mitochondrial membrane potential and induction of mitochondrial dysfunction—while showing lower toxicity to normal cells[2][3][4][6]. Other reported bioactivities include \u03b1-glucosidase inhibition, anti-viral effects, inhibition of amyloid \u03b2 aggregation, and radioprotective properties[5][7]. The primary mechanism of action is ROS (reactive oxygen species) scavenging, likely mediated through both direct antioxidant effects and disruption of mitochondrial ROS signaling pathways in cancer cells.

Other names

planar catechinPCatcatechin planar analogueplanar catechin analogue