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plant-based yellow fever vaccine
- Development stage
- Preclinical
- Lead developer
- Fraunhofer USA Center for Molecular Biotechnology
- Modality
- Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Recombinant Protein Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
The **plant-based yellow fever vaccine** is an experimental subunit vaccine candidate produced in *Nicotiana benthamiana* plants via transient expression. It consists of the yellow fever virus envelope protein (YFE, amino acids 286-682) either as a stand-alone subunit (YFE-1) or fused to bacterial lichenase (LicKM) at different sites (YFE-2E internal loop, YFE-3E C-terminus, YFE-4E N-terminus). YFE targets the elicitation of virus-neutralizing antibodies by mimicking the virus envelope's key immunogenic domains (DI, DII, DIII), which undergo conformational changes for viral fusion. Developed using plant agroinfiltration for scalable, low-cost production with eukaryotic post-translational modifications, preclinical studies in mice showed >70% protection from lethal challenge and high-avidity VN antibodies in nonhuman primates, though efficacy was inferior to live-attenuated 17DD vaccine, suggesting need for adjuvants like Alhydrogel.[1]
- Other names
- YFEYFE-LicKM
02
Targets
YFV E (Yellow fever virus envelope protein)
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