plant sterol-Stanford University

Plant sterol-Stanford University refers to a specific plant sterol (phytosterol) nutraceutical supplement in a gummy format that was evaluated in a Phase 4 clinical trial (NCT04030247) led by Stanford University's South Asian Translational Heart Initiative (SSATHI). The supplement, manufactured by Piper Biosciences, contains 1400 mg of plant sterols per daily dose, administered twice daily. It is designed to lower LDL-cholesterol levels in South Asian patients with low-to-moderate cardiovascular disease risk who do not meet the standard criteria for statin therapy. The mechanism of action involves the competitive inhibition of cholesterol absorption in the intestinal lumen; plant sterols displace dietary and biliary cholesterol from mixed micelles, thereby reducing the amount of cholesterol transported into the bloodstream via the Niemann-Pick C1-Like 1 (NPC1L1) transporter.

Brand names

Piper Gummies

Other names

phytosterolsplant sterolsplant sterol gummy supplement