Drug intelligence / Profile preview

plant sterols + policosanols

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

**Plant sterols + policosanols** is a *combination dietary supplement* that contains both **plant sterols** (phytosterols) and **policosanols**. Plant sterols are plant-derived compounds structurally similar to cholesterol; they act primarily by reducing intestinal absorption of cholesterol, thus lowering LDL cholesterol levels[2][4][7]. Policosanols are a mixture of long-chain aliphatic alcohols, typically derived from sugar cane or other plant sources, and are thought to reduce cholesterol synthesis in the liver, increase the breakdown of LDL cholesterol, and reduce platelet aggregation[3][5][6]. Both components are primarily marketed for *cardiovascular risk reduction and lipid management*, especially in hypercholesterolemia and prevention of coronary heart disease[1][2][5][6].

02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)NPC1L1 (Niemann-pick C1-Like 1 transporter)

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