Drug intelligence / Profile preview

Plantago lanceolata pollen

Development stage
Unknown
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Intradermal, Subcutaneous, Sublingual
01

Overview

Plantago lanceolata pollen, derived from the English or Ribwort plantain weed, is a significant source of airborne allergens that cause seasonal allergic diseases such as rhinoconjunctivitis and asthma during the summer. [1] Its allergenic properties stem from various proteins, with the glycoprotein Pla l 1 being the major allergen and an indicative marker for genuine sensitization. [0] Another identified allergen is the profilin Pla l 2, a panallergen that can cause cross-reactivity. [1] Due to the presence of homologous proteins, sensitization to Plantago lanceolata is often complicated by cross-reactivity with other common pollens like grass, birch, and ash. [0] Extracts of Plantago lanceolata pollen are used clinically for both the diagnosis of allergies via skin prick tests and for treatment through specific allergen immunotherapy (AIT), which aims to desensitize the immune system. [1, 2]

Other names
English plantain pollenRibwort plantain pollenLanceleaf plantain pollenNarrowleaf plantain pollen
02

Targets

A. annua-specific IgE (Artemisia annua-specific immunoglobulin E)

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