plantamajoside

Plantamajoside is a phenylethanoid glycoside and hydroxycinnamic acid derivative found in several plants including Plantago asiatica and Rehmannia glutinosa. It exhibits diverse biological activities such as antioxidant, anti-inflammatory, antibacterial (notably against MRSA via inhibition of sortase A), anti-tumor (including potentiation of metformin-induced apoptosis in liver cancer cells), neuroprotective effects (promoting recovery after spinal cord injury in animal models), and protective effects on pancreatic β-cells in type 2 diabetes mellitus by reducing endoplasmic reticulum stress through upregulation of DNAJC1. Mechanistically, it acts as an inhibitor of the NF-κB pathway and MAPK signaling pathways; it also suppresses Akt/GSK3β signaling. Its antibacterial action is attributed to reversible inhibition of Staphylococcus aureus sortase A (SrtA), thereby reducing bacterial adhesion and biofilm formation[1][2][4][5][7][8][10].

Other names

plantamajosidePlantamosidePurpureaside Adihoside A