Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
plantamajoside
- Development stage
- Preclinical
- Modality
- Targeted Protein Degraders (TPDs) → Small Molecules, Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules, Prodrugs/Conditional Activator Small Molecules → Small Molecules, Multivalent & Scaffold-Based Small Molecules → Small Molecules
- Administration
- Oral, Intraperitoneal, Topical
01
Overview
Plantamajoside is a phenylethanoid glycoside and hydroxycinnamic acid derivative found in several plants including Plantago asiatica and Rehmannia glutinosa. It exhibits diverse biological activities such as antioxidant, anti-inflammatory, antibacterial (notably against MRSA via inhibition of sortase A), anti-tumor (including potentiation of metformin-induced apoptosis in liver cancer cells), neuroprotective effects (promoting recovery after spinal cord injury in animal models), and protective effects on pancreatic β-cells in type 2 diabetes mellitus by reducing endoplasmic reticulum stress through upregulation of DNAJC1. Mechanistically, it acts as an inhibitor of the NF-κB pathway and MAPK signaling pathways; it also suppresses Akt/GSK3β signaling. Its antibacterial action is attributed to reversible inhibition of Staphylococcus aureus sortase A (SrtA), thereby reducing bacterial adhesion and biofilm formation[1][2][4][5][7][8][10].
- Other names
- plantamajosidePlantamosidePurpureaside Adihoside A
02
Targets
NF-κBDNAJC1 (DnaJ heat shock protein family member C1)GSK3 (Glycogen synthase kinase 3 beta)MEKAKT (RAC-alpha serine/threonine-protein kinase)SrtA (Sortase A)
Beyond the preview
Go deeper on plantamajoside.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on plantamajoside.