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Plasma Rich in Growth Factors
- Development stage
- Unknown
- Lead developer
- BTI Biotechnology Institute
- Administration
- Intralesional
01
Overview
Plasma Rich in Growth Factors (PRGF), also referred to in some clinical contexts as PGRF, is an autologous biologic therapy derived from a patient's own blood. It consists of a concentrated preparation of platelets that, upon activation, release a variety of growth factors including PDGF, TGF-beta, and VEGF. Meir Medical Center has evaluated this therapy for the treatment of acute ankle sprains, specifically anterior talofibular ligament (ATFL) tears in athletes. The treatment is administered via ultrasound-guided injection directly into the injured ligament to stimulate tissue regeneration and accelerate the healing process. Clinical trial data indicates that PRGF significantly reduces return-to-play time and residual pain compared to standard saline placebos, making it a promising regenerative modality for sports-related ligamentous injuries.
- Other names
- PRPPlatelet-rich plasmaAutologous platelet-rich plasma
02
Targets
EGFR (Epidermal growth factor receptor)IGF-1R (Insulin-like growth factor 1 receptor)PDGFRA (Platelet-derived growth factor receptor alpha)VEGFR2 (Vascular endothelial growth factor receptor 2)TGFBR (TGF-beta receptor)VEGFR (VEGFR family)
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