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plasmid DNA HIV-1 vaccine
- Development stage
- Unknown
- Lead developer
- Swedish Institute for Infectious Disease Control
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Intradermal
01
Overview
The plasmid DNA HIV-1 vaccine (specifically developed as HIVIS-DNA) is an investigational multigene, multiclade DNA-based vaccine candidate designed to prevent HIV-1 infection. Developed under the HIV Vaccine Immunogenicity Study (HIVIS) program by the Swedish Institute for Infectious Disease Control (SMI) in collaboration with the Karolinska Institutet and Tanzanian partners, the vaccine consists of plasmids encoding HIV-1 genes env (subtypes A, B, C), rev (subtype B), gag (subtypes A, B), and RT (subtype B). It is typically evaluated as a priming agent in a heterologous prime-boost regimen, followed by a boost with the recombinant Modified Vaccinia Ankara (MVA-CMDR) vaccine. The vaccine aims to elicit broad cellular and humoral immune responses against multiple HIV-1 clades.
- Other names
- HIVIS-DNA vaccineHIVIS DNA vaccineHIVIS-03 DNA vaccineHIVIS03 DNA vaccineHIVIS 03 DNA vaccine
02
Targets
Rev (HIV-1 Rev)Human immunodeficiency virus type 1 reverse transcriptaseEnv (HIV-1 envelope glycoprotein)
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