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plasmid DNA vaccine encoding P. yoelii liver-stage antigens
- Development stage
- Preclinical
- Lead developer
- University of Washington
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intradermal, Intramuscular, Intravenous
01
Overview
Plasmid DNA vaccine encoding P. yoelii liver-stage antigens is a preclinical vaccine candidate developed by the University of Washington for the prevention of rodent malaria. It is designed to express Plasmodium yoelii pre-erythrocytic (liver-stage) antigens, such as circumsporozoite protein (CSP) and other candidate antigens (e.g., P36, P52), to prime antigen-specific CD8+ T cell responses in the liver. In preclinical rodent models, this DNA vaccine is typically administered via gene gun or hydrodynamic transfection, often as part of a heterologous 'prime-and-trap' vaccination strategy combined with radiation-attenuated sporozoites (RAS) to recruit and trap memory CD8+ T cells in the liver, thereby reducing liver parasite burden and providing sterile protection against wild-type sporozoite challenge.
- Other names
- P. yoelii liver-stage DNA vaccineplasmid DNA encoding P. yoelii candidate antigensplasmid DNA encoding P. yoelii liver-stage antigens
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