Drug intelligence / Profile preview

platanus acerifolia allergen extract

Development stage
Phase 2
Lead developer
Wolwo Biotech
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous, Sublingual, Intradermal, Intranasal
01

Overview

Platanus acerifolia allergen extract is derived from the pollen of the London plane tree (*Platanus acerifolia*, also known as *Platanus x hispanica*). [4, 8] It is used both for the diagnosis of allergies, typically via skin prick tests, and for allergen-specific immunotherapy to treat conditions like allergic rhinitis, conjunctivitis, and asthma triggered by this pollen. [4, 8, 10, 16] Allergen immunotherapy aims to induce immune tolerance and reduce the severity of allergic symptoms by gradually exposing the patient's immune system to the allergen. The extract contains multiple allergenic proteins, with Pla a 1, Pla a 2, and Pla a 3 being major allergens recognized by the immune systems of sensitized individuals. [4, 5] The clinical trial provided in the context (NCT01739322), sponsored by LETI Pharma, focuses on the biological standardization of the extract for use as a reference preparation. [12]

Brand names
AlustalStaloral
Other names
Platanus x hispanica pollen extractPlatanus hybrida pollen extractLondon plane tree pollen extractAllergenic Extract- London Plane TreePLATANUS X ACERIFOLIA POLLEN
02

Targets

IgE (Immunoglobulin E)

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