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plated Intensive Repair Serum
- Development stage
- Unknown
- Lead developer
- Rion Aesthetics
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Topical
01
Overview
plated Intensive Repair Serum is a topical regenerative skin care product containing human platelet extract (HPE), an allogeneic exosome product derived from US-sourced, leukocyte-reduced apheresed platelets. Developed by the Mayo Clinic in partnership with Rion Aesthetics, the product is formulated with a Vanicream base and consists of platelet-derived extracellular vesicles (exosomes) rich in anti-inflammatory cues and antioxidant enzymes. It is designed to address signs of skin aging and photodamage by targeting cellular senescence markers, telomere damage, and extracellular matrix components. Clinical evaluation in Phase 1 studies has demonstrated its ability to improve various clinical measures of facial photodamage, including fine lines, wrinkles, skin tone, texture, erythema, and pigmentation.
- Brand names
- plated Intensive Repair Serumplated
- Other names
- human platelet extractplatelet-derived exosome productHuman platelet extract (cosmetic product)
02
Targets
CDKN2A (Cyclin-dependent kinase inhibitor 2A)CDKN1A (Cyclin-dependent kinase inhibitor 1A)telomeric G4 (Telomeric DNA G-quadruplex)
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