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platelet-derived growth factor concentrate freeze-dried

Development stage: Unknown
Lead developer: CellSource
Administration: Parenteral

Overview

Platelet-Derived Growth Factor Concentrate Freeze-Dried (PFC-FD™) is an autologous, acellular, lyophilized biologic derived from platelet-rich plasma (PRP), developed by CellSource Co., Ltd. It is produced by processing a patient's own blood to isolate PRP, activating platelets to release growth factors (including PDGF, VEGF, TGF-β, EGF, bFGF, IGF, and HGF), filtering out cellular components, and freeze-drying the resulting concentrate. This process allows for stable room-temperature storage and a higher concentration of growth factors compared to standard PRP. It is primarily investigated for intra-ovarian injection to treat diminished ovarian reserve (DOR) and premature ovarian insufficiency (POI) by stimulating tissue regeneration and folliculogenesis.

Brand names: PFC-FD
Other names: platelet-derived factor concentrate freeze-dry

Targets

MET (Mesenchymal-epithelial transition factor receptor)VEGFR (VEGFR family)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)TGFBR (TGF-beta receptor)FGFR (Fibroblast growth factor receptor)IGF-1R (Insulin-like growth factor 1 receptor)EGFR T790M (Epidermal growth factor receptor T790M mutant)

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