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platelet-poor plasma (Houston Sports Doctor)
- Development stage
- Preclinical
- Modality
- Peripheral Blood HSCs → Hematopoietic Stem Cells → Adult Stem Cells → Stem Cell Therapies → Cell Therapies
- Administration
- Intraarticular, Topical, Intramuscular, Intradiscal
01
Overview
Platelet-poor plasma (PPP) is a blood-derived product obtained by centrifuging whole blood to separate it into its components. It is the plasma fraction that remains after the removal of platelets and red blood cells. [2, 6] While its counterpart, platelet-rich plasma (PRP), is concentrated with growth factors and widely used for tissue regeneration, PPP has a lower concentration of platelets and growth factors and is often used as a placebo or control arm in clinical trials evaluating PRP. [3, 7, 19] However, PPP itself is being investigated for certain therapeutic applications. It can act as a biological scaffold for cell delivery, be used as a tissue sealant due to its fibrinogen content, or serve as a source of other therapeutic proteins like alpha-2-macroglobulin (A2M) for treating low back pain. [1, 2, 5, 12, 18]
- Other names
- autologous platelet poor plasma
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