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platelet-rich fibrin (Misr University for Science and Technology)
- Development stage
- Unknown
- Lead developer
- Misr University for Science and Technology
- Modality
- Cell Therapies
- Administration
- Topical
01
Overview
Platelet-rich fibrin (PRF) is a second-generation autologous platelet concentrate obtained from a patient's own blood through centrifugation without the addition of anticoagulants or bovine thrombin. It consists of a fibrin matrix polymerized in a tetra-molecular structure that traps platelets, leukocytes, and cytokines. In the context of dental implantology and oral surgery, PRF is utilized as a biological membrane to promote tissue healing and osseointegration. It acts as a reservoir for the sustained release of growth factors, including transforming growth factor-beta (TGF-β), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF), which stimulate angiogenesis and osteoblast proliferation. This specific application by Misr University for Science and Technology evaluates the efficacy of locally delivered PRF compared to melatonin gel in enhancing the stability and integration of dental implants in patients with tooth loss.
- Other names
- PRFChoukroun's PRFplatelet-rich fibrin membrane
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