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platelet-rich fibrin (Pamukkale University)
- Development stage
- Unknown
- Lead developer
- Pamukkale University
- Modality
- Cell Therapies
- Administration
- Intracochlear
01
Overview
Platelet-rich fibrin (PRF) is an autologous, second-generation platelet concentrate prepared from a patient's own blood through centrifugation without the addition of anticoagulants. It consists of a dense fibrin matrix that traps platelets, leukocytes, and a high concentration of growth factors, including platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and vascular endothelial growth factor (VEGF). In clinical research conducted by Pamukkale University, PRF is administered intracochlearly during cochlear implantation surgery. The primary objective is to leverage its anti-inflammatory and regenerative properties to mitigate surgical trauma-induced fibrosis. By reducing the fibrotic cascade, PRF aims to enhance the effectiveness of the cochlear implant and decrease its power consumption in patients with sensorineural hearing loss.
- Other names
- PRFautologous platelet-rich fibrinintracochlear platelet rich fibrin
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