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platelet rich fibrin + retinol
- Development stage
- Unknown
- Lead developer
- Cairo University
- Modality
- Small Molecules
- Administration
- Implant, Topical
01
Overview
Platelet rich fibrin + retinol is an investigational regenerative medicine combination consisting of autologous platelet-rich fibrin (PRF) and retinol (Vitamin A). Developed and studied by researchers at Cairo University, this combination is designed for use in periodontal regenerative therapy, specifically for the treatment of intrabony (intra-osseous) periodontal defects in patients with periodontitis. PRF serves as a second-generation autologous platelet concentrate scaffold rich in growth factors (such as PDGF and TGF-beta) and fibrin, while the addition of retinol is hypothesized to enhance the regenerative potential by promoting osteogenic differentiation and accelerating wound healing cascades. The combination is typically applied as a biologically-derived scaffold or biomaterial within the periodontal defect during surgical procedures to facilitate tissue repair.
- Other names
- retinol-augmented PRFvitamin A added to PRFVitamin A + PRF
02
Targets
TGFBR (TGF-beta receptor)PDGFRA (Platelet-derived growth factor receptor alpha)RARA (Retinoic acid receptor alpha)Transthyretin – Retinol-binding protein 4 interfaceRBP4 (Retinol-binding protein 4)
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