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platelet-rich plasma (Stanford University)
- Development stage
- Unknown
- Lead developer
- Stanford University
- Modality
- Cell Therapies
- Administration
- Intratesticular
01
Overview
Platelet-rich plasma (PRP) is an investigational autologous biologic therapy being studied by Stanford University for the treatment of nonobstructive azoospermia (NOA). The therapy involves the preparation of a concentrated platelet fraction from the patient's own peripheral blood, which is then administered via intratesticular injection. This biologic product contains a high concentration of growth factors (such as PDGF, TGF-β, and VEGF) and cytokines that are hypothesized to promote tissue repair, reduce local inflammation, and potentially stimulate or restore spermatogenesis. The primary clinical focus of this specific protocol (NCT05479474) is to determine if intratesticular PRP injections can improve sperm retrieval rates and subsequent IVF outcomes in infertile men who have previously undergone a failed testicular sperm extraction (TESE) procedure.
- Other names
- PRPautologous platelet-rich plasmaintratesticular platelet-rich plasma
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